Is it safe to take Dihydrocodeine with other medications?
Key Takeaways
Dihydrocodeine and painkillers: Dihydrocodeine can be safely combined with some over-the-counter painkillers, like paracetamol and ibuprofen, but should not be used with other codeine-containing painkillers due to the risk of increased side effects.
Risk of interactions with sleeping pills: Combining dihydrocodeine with sleeping pills like Zopiclone can be dangerous due to their similar sedative effects, which can lead to slowed breathing and other life-threatening side effects.
Consult with a doctor: Before taking dihydrocodeine with other medications, especially sleeping pills, diarrhoea medications, or MAOIs, it's important to consult with your doctor to avoid harmful interactions.
Dihydrocodeine is a commonly prescribed painkiller for moderate to severe pain, but many people wonder whether it’s safe to combine it with other medications. In this guide, we’ll explore how dihydrocodeine interacts with other drugs, including painkillers, sleeping pills, and more. We’ll provide advice on when to consult your doctor to ensure the safe use of this potent opioid.
What is Dihydrocodeine Used For?
Dihydrocodeine is an opioid painkiller commonly used to treat moderate to severe pain, such as that experienced after surgery or from chronic conditions like osteoarthritis (Moore et al, 2000). It works by blocking pain signals in the brain, providing effective relief for individuals suffering from debilitating pain. In addition to pain relief, dihydrocodeine can also act as a cough suppressant for severe coughing.
Does Dihydrocodeine Interact with Other Painkillers?
Dihydrocodeine can be safely combined with certain over-the-counter painkillers, such as paracetamol, ibuprofen, and aspirin. However, it’s important to avoid combining it with painkillers that contain codeine as this can increase the likelihood of side effects, such as nausea, dizziness, and respiratory depression. Examples of such combinations include:
Co-codamol
Nurofen Plus
Co-codaprin
Solpadeine
If you're unsure about combining dihydrocodeine with any other pain medications, it's essential to consult your doctor or pharmacist.
Does Dihydrocodeine Interact with Sleeping Pills?
Combining dihydrocodeine with sleeping pills can be dangerous. Both medications act as central nervous system depressants, meaning they slow down brain activity, which can lead to excessive sedation. Taking both together can significantly increase the risk of respiratory depression (slowed or stopped breathing), which can be life-threatening.
The NHS advises against using dihydrocodeine with sleeping pills such as Zopiclone unless directed by a healthcare professional. Always speak to your GP before combining these medications to ensure your safety.
Does Dihydrocodeine Interact with Diarrhoea Medications?
Dihydrocodeine can interact with certain medications used to treat diarrhoea, particularly those containing loperamide. Both dihydrocodeine and loperamide work by slowing down intestinal movement, but when taken together, they can cause severe constipation. In some cases, this can lead to dangerous gastrointestinal problems.
If you need to take both dihydrocodeine and diarrhoea medication, consult your doctor for guidance on safe usage and to prevent any complications.
Does Dihydrocodeine Interact with Monoamine Oxidase Inhibitors (MAOIs)?
Yes, dihydrocodeine can interact with MAOIs, which are medications used to treat depression and some other conditions. Combining dihydrocodeine with MAOIs (or taking them within 14 days of stopping MAOIs) can lead to a dangerous condition known as serotonin syndrome. This occurs when serotonin levels in the brain become too high and can cause symptoms such as:
Shivering
Diarrhoea
Muscle rigidity
High fever
Seizures
If you’re on an MAOI, never take dihydrocodeine without first consulting your doctor.
Should I Consult My Doctor Before Starting Treatment with Dihydrocodeine?
Yes, it is important to consult your GP before starting treatment with dihydrocodeine or any new medication. Dihydrocodeine is a potent opioid painkiller with the potential for side effects and drug interactions. Your doctor can assess whether dihydrocodeine is appropriate for your condition, prescribe the right dosage, and guide you on how to use it safely. Regular check-ups are essential to monitor its effectiveness and minimise risks.
Final Thoughts
Dihydrocodeine is an effective painkiller, but it must be used with care, especially when combined with other medications. Always follow your doctor’s advice and be cautious when using it alongside painkillers, sleeping pills, or other drugs. If you're considering taking dihydrocodeine with other medications, consult your healthcare provider to ensure it’s safe and appropriate for you.
Medically Reviewed by:
Dr. Irfan Siddique MBBS
GMC reference no: 7694522
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